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Ongoing impairments following transient ischaemic attack: retrospective cohort study
G M Turner1, M Calvert2, M G Feltham2
1Institute of Applied Health Research, University of Birmingham, Birmingham, UK. g.turner.1@bham.ac.uk.
European Journal of Neurology
|July 20, 2016
Summary
Transient ischaemic attack (TIA) patients frequently experience ongoing fatigue, psychological, and cognitive impairments. These residual effects require clinical consideration beyond stroke prevention after TIA symptoms resolve.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Clinical management post-transient ischaemic attack (TIA) primarily focuses on stroke prevention.
- Emerging evidence suggests TIA patients may suffer from persistent residual impairments.
- Understanding these post-TIA sequelae is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the association between a first transient ischaemic attack (TIA) and subsequent consultations for specific impairments.
- To quantify the risk of developing fatigue, psychological, and cognitive impairments after TIA.
- To inform clinical practice regarding the long-term effects of TIA.
Main Methods:
- Retrospective matched-cohort study utilizing The Health Improvement Network (THIN) primary care database.
- Inclusion of adults (≥18 years) with a first TIA between 2009-2013, matched 1:5 to controls.
- Kaplan-Meier analysis and adjusted hazard ratios used to estimate time to first consultation for fatigue, psychological, or cognitive impairment.
Main Results:
- 9419 TIA patients and 46,511 controls were analyzed.
- TIA patients showed significantly higher consultation rates for fatigue, psychological, and cognitive impairments (P < 0.0001).
- Adjusted hazard ratios indicated increased risk for TIA patients: 1.43 for fatigue, 1.26 for psychological, and 1.45 for cognitive impairment.
Conclusions:
- Transient ischaemic attack is significantly linked to increased consultations for fatigue, psychological, and cognitive issues.
- These findings highlight the presence of impairments even after initial TIA symptoms subside.
- Clinicians should consider these residual impairments in the holistic management of TIA patients.
Keywords:
UKanxietycognitive impairmentdepressionfatigueprimary care databasetransient ischemic attackMore Related Videos
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