Related Experiment Video

Updated: Mar 17, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

13.2K

Better Nanoparticle Targeting with P-Selectin

    Cancer Discovery
    |July 21, 2016
    PubMed

    Insights

    Researchers found that P-selectin, an adhesion molecule, can be targeted to deliver drugs via nanoparticles to tumors in mice. This method shows promise for cancer treatment, even in noninflammatory tumors after radiation therapy.

    Area of Science:

    • Oncology
    • Biomedical Engineering
    • Immunology

    Background:

    • P-selectin is an adhesion molecule expressed on the endothelium during inflammation.
    • Targeted drug delivery systems are crucial for effective cancer therapy.
    • Nanoparticle-based drug delivery offers potential for enhanced therapeutic outcomes.

    Purpose of the Study:

    • To investigate P-selectin as a target for nanoparticle delivery to tumors.
    • To evaluate the antitumor efficacy of P-selectin-targeted nanoparticles.
    • To explore methods for enhancing P-selectin expression in noninflammatory tumors.

    Main Methods:

    • Utilized mouse models of cancer.
    • Administered drug-filled nanoparticles targeting P-selectin.
    • Employed ionizing radiation to induce P-selectin expression on tumor vasculature.

    Main Results:

    • Achieved significant antitumor efficacy in multiple cancer models.
    • Demonstrated successful drug delivery to noninflammatory tumors by inducing P-selectin expression.
    • Validated P-selectin as a viable target for nanoparticle-mediated cancer therapy.

    Conclusions:

    • P-selectin targeting represents a promising strategy for nanoparticle-based cancer drug delivery.
    • Ionizing radiation can be used to enhance the applicability of this approach to noninflammatory tumors.
    • This study provides a foundation for developing novel targeted cancer therapies.

    More Related Videos

    Biofunctionalization of Magnetic Nanomaterials06:40

    Biofunctionalization of Magnetic Nanomaterials

    Published on: July 16, 2020

    3.1K
    Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles08:26

    Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

    Published on: October 19, 2015

    12.8K

    Related Concept Videos

    Selectins01:25

    Selectins

    Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
    4.7K
    Modified-Release Drug Delivery Systems: Site-Targeted01:24

    Modified-Release Drug Delivery Systems: Site-Targeted

    Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
    73
    Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

    Site-Targeted Drug Delivery Systems: Polymeric Carriers

    Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
    82