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Updated: Mar 17, 2026
10:38
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
13.2K
Summary
Researchers found that P-selectin, an adhesion molecule, can be targeted to deliver drugs via nanoparticles to tumors in mice. This method shows promise for cancer treatment, even in noninflammatory tumors after radiation therapy.
Area of Science:
- Oncology
- Biomedical Engineering
- Immunology
Background:
- P-selectin is an adhesion molecule expressed on the endothelium during inflammation.
- Targeted drug delivery systems are crucial for effective cancer therapy.
- Nanoparticle-based drug delivery offers potential for enhanced therapeutic outcomes.
Purpose of the Study:
- To investigate P-selectin as a target for nanoparticle delivery to tumors.
- To evaluate the antitumor efficacy of P-selectin-targeted nanoparticles.
- To explore methods for enhancing P-selectin expression in noninflammatory tumors.
Main Methods:
- Utilized mouse models of cancer.
- Administered drug-filled nanoparticles targeting P-selectin.
- Employed ionizing radiation to induce P-selectin expression on tumor vasculature.
Main Results:
- Achieved significant antitumor efficacy in multiple cancer models.
- Demonstrated successful drug delivery to noninflammatory tumors by inducing P-selectin expression.
- Validated P-selectin as a viable target for nanoparticle-mediated cancer therapy.
Conclusions:
- P-selectin targeting represents a promising strategy for nanoparticle-based cancer drug delivery.
- Ionizing radiation can be used to enhance the applicability of this approach to noninflammatory tumors.
- This study provides a foundation for developing novel targeted cancer therapies.
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