Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

18.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
18.2K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

709
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
709
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

897
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
897
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

848
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
848
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

13.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.7K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

1.1K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The chemistry, biology and pharmacology of the cyclopentenone prostaglandins.

Prostaglandins & other lipid mediators·2020
Same author

Eicosanoid mediation of cannabinoid actions.

Bioorganic & medicinal chemistry·2019
Same author

Ajulemic acid: potential treatment for chronic inflammation.

Pharmacology research & perspectives·2018
Same author

<i>N-</i>Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential.

Molecular pharmacology·2017
Same author

In vitro metabolism and metabolic effects of ajulemic acid, a synthetic cannabinoid agonist.

Pharmacology research & perspectives·2014
Same author

Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity.

Bioorganic & medicinal chemistry·2014

Related Experiment Video

Updated: Mar 17, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

1.3K

Cannabinoids, inflammation, and fibrosis.

Robert B Zurier1,2, Sumner H Burstein3,4

  • 1Department of Medicine University of Massachusetts Medical School, Worcester, Massachusetts; and robert.zurier@umassmed.edu.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 21, 2016
PubMed
Summary
This summary is machine-generated.

Cannabinoids offer a novel approach to treating inflammation and fibrosis, distinct from NSAIDs and with fewer side effects. Research explores various natural and synthetic cannabinoids for their therapeutic potential.

Keywords:
anti-inflammatoryantifibroticendocannabinoidsspecialized proresolving mediators

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 17, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

1.3K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.3K

Area of Science:

  • Pharmacology
  • Immunology
  • Natural Product Chemistry

Background:

  • Cannabinoids exhibit anti-inflammatory properties through mechanisms distinct from NSAIDs.
  • Unlike NSAIDs, cannabinoids generally lack adverse effects, presenting a new therapeutic avenue.
  • Inflammation and fibrosis are key pathological features in numerous diseases.

Purpose of the Study:

  • To review the anti-inflammatory actions of various phytocannabinoids.
  • To discuss synthetic cannabinoid preparations with anti-inflammatory effects.
  • To explore the potential of cannabinoids in treating inflammation and fibrosis.

Main Methods:

  • Literature review of anti-inflammatory actions of phytocannabinoids (THC, cannabidiol, etc.).
  • Survey of non-cannabinoid plant components and pyrolysis products.
  • Discussion of synthetic cannabinoids (nabilone, dronabinol, Sativex, ajulemic acid) and endogenous cannabinoids.

Main Results:

  • Phytocannabinoids like THC and cannabidiol demonstrate anti-inflammatory effects.
  • Synthetic cannabinoids, including ajulemic acid, show promise in preclinical and clinical studies.
  • Endogenous cannabinoids and related compounds also possess anti-inflammatory and antifibrotic properties.

Conclusions:

  • Cannabinoids represent promising candidates for developing novel anti-inflammatory and antifibrotic agents.
  • Their unique mechanisms and safety profile offer advantages over traditional therapies.
  • Targeting chronic inflammation, a significant unmet medical need, is a key area for cannabinoid research.