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Updated: Mar 17, 2026

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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[Intraoperative optical coherence tomography in corneal and glaucoma surgical procedures]
S Siebelmann1,2, B Bachmann3, A Lappas3
1Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland. Sebastian.Siebelmann@uk-koeln.de.
Summary
Intraoperative optical coherence tomography (OCT) provides real-time imaging superior to surgical microscopes in cornea and glaucoma surgery. While it visualizes hidden structures, shadowing from instruments and a lack of randomized trials are current limitations.
Area of Science:
- Ophthalmology
- Surgical Imaging
- Medical Technology
Background:
- Optical coherence tomography (OCT) is the gold standard for anterior and posterior segment imaging.
- OCT integration into surgical microscopes enables intraoperative use in anterior segment surgery.
- OCT excels at imaging thin or transparent structures crucial in corneal and glaucoma procedures.
Purpose of the Study:
- To provide an overview of the opportunities offered by intraoperative OCT in cornea and glaucoma surgery.
- To highlight the advantages of intraoperative OCT over standard surgical microscopes.
Main Methods:
- Analysis of recent literature from PubMed.
- Inclusion of own clinical experience from the Center for Ophthalmology, University Hospital of Cologne.
Main Results:
- Intraoperative OCT provides real-time imaging during corneal and glaucoma surgeries.
- Clinical studies demonstrate benefits in procedures like DMEK, DALK, DSAEK, Boston Keratoprosthesis, canaloplasty, and trabectome surgery.
- OCT visualizes structures not discernible with a standard surgical microscope.
Conclusions:
- Intraoperative OCT offers high-resolution, real-time imaging, delivering supplementary information in glaucoma and corneal surgery.
- Shadowing from surgical instruments presents a significant challenge.
- A primary limitation is the current scarcity of randomized-controlled trials evaluating microscope-integrated intraoperative OCT's benefits.
Keywords:
CanaloplastyDeep anterior lamellar keratoplastyDescemet membrane endothelial keratoplastyDescemet’s stripping automated endothelial keratoplastySurgical microscopeMore Related Videos
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