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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Kidney Function Does Not Modify the Favorable Quality of Life Changes Associated With Revascularization for Coronary

Matthew T James1, Stephen B Wilton2, Fiona M Clement3

  • 1Department of Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada Department of Community Health Sciences, University of Calgary, Alberta, Canada mjames@ucalgary.ca.

Journal of the American Heart Association
|July 21, 2016
PubMed

Insights

Kidney function does not impact quality of life improvements after coronary revascularization procedures like CABG or PCI, or with medical therapy. These findings suggest similar benefits across different kidney function levels for patients with coronary artery disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Health Services Research

Background:

  • Patients with kidney disease undergoing coronary revascularization face higher complication risks, potentially impacting quality of life.
  • Assessing health-related quality of life (HR-QOL) is crucial for understanding treatment outcomes in these patients.

Purpose of the Study:

  • To investigate the relationship between kidney function and changes in HR-QOL after coronary revascularization or medical management.
  • To determine if estimated glomerular filtration rate (eGFR) influences HR-QOL outcomes in patients with coronary artery disease.

Main Methods:

  • A cohort study of 8198 adults who underwent coronary angiography between 2004 and 2008 in Alberta.
  • Collected data on HR-QOL using EuroQol 5 dimensions (EQ-5D) and Seattle Angina Questionnaire (SAQ) surveys.
  • Analyzed changes in HR-QOL measures in relation to eGFR and treatment strategy (CABG, PCI, medical therapy).

Main Results:

  • HR-QOL improvements were most favorable with coronary artery bypass graft (CABG) but did not significantly differ by kidney function within treatment groups.
  • Adjusted mean EQ-5D utility scores increased similarly across all eGFR levels for CABG, PCI, and medical management groups.
  • Seattle Angina Questionnaire (SAQ) scores for quality of life, angina frequency, and other domains also showed similar changes across eGFR levels within each treatment group.

Conclusions:

  • Health-related quality of life changes do not vary by kidney function in patients undergoing CABG, PCI, or medical management for coronary disease.
  • These findings suggest that kidney function should not be a barrier to selecting appropriate coronary disease treatment strategies.
  • Revascularization and medical management offer comparable HR-QOL benefits irrespective of the patient's level of kidney function.
Abstract

Keywords:
chronic kidney diseasecoronary diseasehealth‐related quality of lifekidneyrevascularization

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