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Related Experiment Videos

"Empty sella" with invasive microprolactinoma.

T J Hufnagel1, J H Kim, J D Wiedenmann

  • 1Section of Neuropathology, Yale University School of Medicine, New Haven, CT 06510.

Clinical Neuropathology
|May 1, 1989
PubMed
Summary

An aggressive pituitary tumor invaded the sphenoid sinus with an empty sella, remaining undiagnosed. The study suggests "empty sella" is imprecise, advocating for "intrasellar arachnoidocele" or "subarachnoid herniation" for better description.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Pathology

Background:

  • Pituitary microadenomas can present with diverse clinical manifestations.
  • Empty sella syndrome is a recognized anatomical finding, but its underlying pathology can vary.
  • Accurate terminology is crucial for precise medical communication and diagnosis.

Observation:

  • A rare case of an aggressive prolactin-secreting pituitary microadenoma invading the sphenoid sinus was identified.
  • This microadenoma was associated with an empty sella configuration.
  • The pituitary tumor remained clinically undiagnosed during the patient's lifetime.

Findings:

  • The postmortem examination revealed the anatomical details of the pituitary tumor and the associated empty sella.
  • The study highlights a unique association between a specific type of pituitary tumor and the empty sella.

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  • The term "empty sella" poorly correlates with the actual underlying pathology in this case.

    • Implications:

    • The findings challenge the universal acceptance of the term "empty sella" due to its lack of specificity.
    • More descriptive terms like "intrasellar arachnoidocele" or "intrasellar subarachnoid herniation" are proposed for better pathological correlation.
    • Improved terminology could enhance diagnostic accuracy and understanding of pituitary pathologies.