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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

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Related Experiment Video

Updated: Mar 17, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Evolutionary clues in lncRNAs.

Anne Nitsche^1,2, Peter F Stadler^{1,3,4,5,6,7,8}

¹Bioinformatics Group, Department of Computer Science, University Leipzig, Leipzig, Germany.

Wiley Interdisciplinary Reviews. RNA

|July 21, 2016

Summary

This summary is machine-generated.

Long non-coding RNAs (lncRNAs) show limited primary sequence conservation but maintain functional importance through conserved secondary structures and expression patterns, despite rapid evolution.

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Area of Science:

Genomics
Evolutionary Biology
RNA Biology

Background:

The human transcriptome contains diverse long non-coding RNAs (lncRNAs) with largely unexplored functions.
Understanding lncRNA conservation and evolution is crucial due to pervasive transcription of the non-coding genome.

Purpose of the Study:

To investigate the evolutionary patterns and conservation of lncRNAs.
To explore the functional implications of lncRNA sequence and structural conservation.

Main Methods:

Analysis of primary sequence conservation across species.
Computational methods to assess interspecies conservation of lncRNA secondary structures.
Examination of selective constraints on non-coding gene structures and spatio-temporal expression patterns.

Main Results:

Most lncRNAs exhibit weak or untraceable primary sequence conservation.
Interspecies conservation of secondary structures is observed among lncRNA homologs, suggesting structural importance for function.
Selective constraints on gene structures and conserved expression patterns provide further evolutionary insights.

Conclusions:

lncRNA functionality is more dependent on conserved secondary structures than primary sequences.
Despite rapid evolutionary turnover, conserved structural and expression features highlight functional significance.
Further research is needed to fully understand the functional meaning of lncRNA evolution.