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Oncogenic osteomalacia. A case report.

M H McGuire1, J T Merenda, J R Etzkorn

  • 1Department of Orthopedic Surgery, St. Louis University School of Medicine, Missouri.

Clinical Orthopaedics and Related Research
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

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Oncogenic osteomalacia, a rare disorder causing bone pain and fractures due to low vitamin D, can be cured by surgically removing the associated tumor. Early diagnosis and treatment are crucial for patient recovery.

Area of Science:

  • Endocrinology
  • Oncology
  • Orthopedics

Background:

  • Oncogenic osteomalacia is a rare paraneoplastic syndrome.
  • It presents with hypophosphatemia, hyperphosphaturia, and low 1,25-dihydroxyvitamin D.
  • This condition is linked to neoplastic processes causing phosphate wasting.

Observation:

  • The authors describe a patient diagnosed with oncogenic osteomalacia.
  • The associated tumor, a benign mesenchymal neoplasm, was not immediately detected.
  • Diagnosis was established based on clinical and laboratory findings.

Findings:

  • Despite delayed tumor detection, oncogenic osteomalacia was diagnosed.
  • Magnetic resonance imaging (MRI) was instrumental in locating the tumor.
  • Surgical resection of the tumor led to the patient's cure.

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Implications:

  • This case highlights the importance of suspecting oncogenic osteomalacia in patients with unexplained hypophosphatemia and bone disease.
  • Prompt diagnosis and surgical management of the underlying tumor are critical for successful treatment.
  • Early detection and intervention can prevent long-term complications associated with this rare condition.