Related Experiment Video
Updated: Mar 17, 2026
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
3.0K
Expression of evolutionarily novel genes in tumors
1The Biomedical Center and Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Infectious Agents and Cancer
|July 21, 2016
Summary
Newly identified genes, termed tumor specifically expressed, evolutionarily novel (TSEEN) genes, are found in tumors. Their specific expression and positive selection suggest a role in tumor development and potentially beneficial new functions.
Area of Science:
- Genomics
- Evolutionary Biology
- Cancer Research
Background:
- Evolutionarily novel genes arise through various molecular mechanisms.
- The expression of these novel genes in tumors is a poorly understood phenomenon.
- Some novel genes show highly specific expression patterns within tumors.
Purpose of the Study:
- To investigate the phenomenon of evolutionarily novel genes expressed in tumors.
- To propose a new term for this biological observation: TSEEN genes.
- To explore the potential functional significance of these genes in cancer.
Main Methods:
- Analysis of gene expression data in tumor tissues.
- Comparative genomics to identify evolutionarily novel genes.
- Phylogenetic analysis to assess selection pressures.
Main Results:
- Identified specific expression of evolutionarily novel genes in various tumors.
- Observed positive selection for several human tumor-related genes in primate evolution.
- These findings suggest a potential role for novel genes in tumor biology.
Conclusions:
- The expression of evolutionarily novel genes in tumors represents a significant biological phenomenon.
- TSEEN genes may contribute to the development of new functions beneficial to organisms, including in the context of cancer.
- Further research into TSEEN genes could reveal novel therapeutic targets or biomarkers.
More Related Videos
Related Concept Videos
01:33Cancer-Critical Genes I: Proto-oncogenes
11.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.8K
01:33Cancer-Critical Genes I: Proto-oncogenes
5.9K
5.9K
03:21Genome Size and the Evolution of New Genes
9.4K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.4K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
2.9K
2.9K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
10.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
01:12Loss of Tumor Suppressor Gene Functions
6.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.2K