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The Association between Helicobacter pylori Infection and Body Weight among Children
Jun Sik Choi1, Kyung Og Ko1, Jae Woo Lim1
1Department of Pediatrics, Konyang University College of Medicine, Daejeon, Korea.
Insights
Helicobacter pylori infection was not linked to obesity in children. However, eradicating H. pylori significantly increased body weight in treated children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Helicobacter pylori (H. pylori) infection is common in children.
- The relationship between H. pylori infection and body weight, particularly obesity, remains unclear.
- Understanding this association is crucial for pediatric health management.
Purpose of the Study:
- To investigate the association between H. pylori infection and body weight in children.
- To determine if H. pylori infection prevalence differs between obese and non-obese children.
- To assess the impact of H. pylori eradication on body weight changes.
Main Methods:
- A retrospective study analyzed pediatric patients undergoing H. pylori immunoglobulin G testing.
- Patients were categorized as H. pylori seropositive or seronegative.
- Comparisons were made between infected and non-infected groups, and between obese and non-obese children. Body weight changes after H. pylori eradication treatment were also evaluated.
Main Results:
- No significant difference in weight or laboratory data was found between H. pylori seropositive and seronegative children.
- The prevalence of H. pylori infection did not differ between obese and non-obese children.
- Children who underwent H. pylori eradication treatment showed a significant increase in body weight after 2 months compared to untreated children.
Conclusions:
- Obesity in children is not associated with H. pylori infection.
- H. pylori eradication therapy leads to a significant increase in body weight.
- Further research may explore the mechanisms behind H. pylori's impact on weight regulation.
Purpose:
We performed to reveal the association between the Helicobacter pylori infection and body weight among children.
Methods:
Out retrospective study included patients who underwent the H. pylori immunoglobulin G testing at Konyang University Hospital between March 2011 and June 2014. These patients were classified as seropositive (28 boys, 27 girls; mean age: 9.89±3.28 years) or seronegative (55 boys, 54 girls; mean age: 9.84±3.02 years). Next, we compared various characteristics between the seropositive and negative groups, as well as between obese children (body weight ≥90th percentile) and non-obese children (body weight <90th percentile). Furthermore, we compared the change in body weight after 2 months of treatment with amoxicillin, clarithromycin and omeprazole among the 55 seropositive children (14 treated children and 41 non-treated children).
Results:
There were no differences in the weights and laboratory data for the 55 seropositive children and 109 seronegative children (weight; 40.96±18.11 kg vs. 36.85±13.72 kg, respectively; p=0.14). And, there was no difference in the prevalence of H. pylori infection among the 29 obese and 135 non-obese children (p=0.581). However, after 2 months of eradication, the 14 treated patients exhibited a significant weight gain (+0.91±0.52 kg), compared to the 41 non-treated patients (-0.29±1.16 kg, p=0.025).
Conclusion:
Our findings present that obesity was not associated with the H. pylori infection, although H. pylori eradication led to significant increase in body weight.
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