Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum trace elements in juvenile chronic arthritis.

V Honkanen1, P Pelkonen, H Mussalo-Rauhamaa

  • 1Children's Hospital, University of Helsinki, Finland.

Clinical Rheumatology
|March 1, 1989
PubMed
Summary

Serum zinc and selenium are lower, while copper is higher in children with juvenile chronic arthritis (JCA). These trace element imbalances correlate with disease severity and duration, impacting arthritis management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bed sensor ballistocardiogram for non-invasive detection of atrial fibrillation: a comprehensive clinical study.

Physiological measurement·2025
Same author

Androgen deprivation and SARS-CoV-2 in men with prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

The specific sorption of Np(V) on the corundum (α-Al2O3) surface in the presence of trivalent lanthanides Eu(III) and Gd(III): A batch sorption and XAS study.

Journal of colloid and interface science·2016
Same author

The microbial impact on the sorption behaviour of selenite in an acidic, nutrient-poor boreal bog.

Journal of environmental radioactivity·2015
Same author

Factors affecting the sorption of cesium in a nutrient-poor boreal bog.

Journal of environmental radioactivity·2015
Same author

Sorption of radioiodide in an acidic, nutrient-poor boreal bog: insights into the microbial impact.

Journal of environmental radioactivity·2015

Area of Science:

  • Pediatric Rheumatology
  • Nutritional Biochemistry

Background:

  • Juvenile chronic arthritis (JCA) is a significant pediatric autoimmune condition.
  • Trace elements play crucial roles in immune function and inflammation.

Purpose of the Study:

  • To investigate serum concentrations of zinc, copper, and selenium in children with JCA.
  • To compare these levels with healthy controls and correlate them with disease characteristics.

Main Methods:

  • Serum samples were collected from 125 JCA patients and a control group of healthy children.
  • Concentrations of zinc, copper, and selenium were measured.
  • Data were analyzed for correlations with disease type (oligoarthritis vs. polyarthritis), hemoglobin, erythrocyte sedimentation rate (ESR), and disease duration.

Related Experiment Videos

Main Results:

  • Children with JCA exhibited lower serum zinc and selenium, and higher copper levels compared to healthy children.
  • Polyarthritis patients showed higher copper and lower zinc than oligoarthritis patients.
  • Serum zinc correlated inversely with ESR and directly with hemoglobin; copper correlated directly with ESR.
  • Low selenium levels were observed in patients with long-standing arthritis.

Conclusions:

  • Distinct serum trace element abnormalities are present in JCA.
  • These imbalances, particularly copper and zinc levels, are associated with disease activity and type.
  • Trace element status may be a relevant factor in the pathophysiology and management of JCA.