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Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status
R Thulasi Raman1, D Manimaran2, Praveen Rachakatla3
1Assistant Professor, Department of Pathology, Shri Sathya Sai Medical College and Research Institute , Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu, India .
Journal of Clinical and Diagnostic Research : JCDR
|July 21, 2016
Summary
HIV infection significantly impacts coagulation, with decreased platelet counts and prolonged clotting times (PT and aPTT). Activated partial thromboplastin time (aPTT) inversely correlates with CD4 count, suggesting its utility in assessing HIV severity.
Area of Science:
- Hematology
- Infectious Diseases
- Clinical Pathology
Background:
- Human Immunodeficiency Virus (HIV) infection is associated with various coagulation abnormalities, particularly in advanced stages.
- These hemostatic alterations can impact disease progression and patient management.
Purpose of the Study:
- To investigate platelet count, prothrombin time (PT), and activated partial thromboplastin time (aPTT) in HIV-infected individuals.
- To correlate these coagulation parameters with CD4+ T-cell counts and antiretroviral therapy (ART) status.
Main Methods:
- A case-control study involving 120 HIV patients and 40 healthy controls.
- Blood samples analyzed for platelet count, PT, aPTT, and CD4 count.
- Statistical analysis performed using a statistical package.
Main Results:
- HIV patients exhibited significantly lower platelet counts compared to controls.
- Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were significantly prolonged in HIV patients.
- Activated partial thromboplastin time (aPTT) showed a significant inverse correlation with CD4 count.
- No significant differences in coagulation parameters were observed between patients on ART and those not on ART.
Conclusions:
- Platelet count, PT, and particularly aPTT can serve as accessible screening tools for assessing HIV severity.
- These basic coagulation tests are valuable in resource-limited settings where CD4+ T-cell enumeration may not be readily available.
