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Published on: May 18, 2021
Ehlers-Danlos syndrome type IV (EDS IV) as model of a defective biopolymer composite material
T Nemetschek1, W Folkhard, E Knörzer
1Department of Ultrastructure Research, University of Heidelberg, Germany.
Abstract:
The connective tissue of a lethal EDS IV case was investigated for the reasons of the manifested disturbances of the arterial wall. This functional disorder was attributed to the mechanical decoupling of elastin and collagen, with the premise of a composite material consisting of cellular, fibrillar, lamellar and other matrix components. A conceivable relation between the manifested deficiency of type III collagen and a disturbed anchoring of elastin is shown. These findings are supported by biochemical, morphological, x-ray and mechanical data.
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