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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Papillary Dermis01:11

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Dermis
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Updated: Mar 17, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Dermatofibroma simulating seborrheic keratosis dermoscopically.

Daniel Holanda Barroso1, Camila Pinon Zoby Leite1, Gabriela Diniz de Souza Araujo1

  • 1Universidade de Pernambuco (UPE) - Recife (PE), Brazil.

Anais Brasileiros De Dermatologia
|July 21, 2016
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Summary

Dermatofibroma diagnosis can be challenging as it mimics other skin conditions. This case highlights a dermatofibroma with dermoscopic features typically seen in seborrheic keratosis, emphasizing atypical presentations.

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Area of Science:

  • Dermatology
  • Dermopathology
  • Oncology

Background:

  • Dermatofibroma is a common benign skin tumor with typically straightforward clinical diagnosis.
  • Dermoscopy aids in diagnosing dermatofibroma, usually showing a scar-like central area and a peripheral pigment network.
  • Atypical dermoscopic presentations can complicate the diagnosis of dermatofibroma.

Observation:

  • This report details a rare case of dermatofibroma.
  • The dermatofibroma presented with unusual dermoscopic features.
  • These features included ridges, furrows, and pseudocomedos.

Findings:

  • The observed dermoscopic pattern mimicked that of seborrheic keratosis.
  • This atypical presentation underscores the variability in dermatofibroma dermoscopy.
  • The classical dermoscopic signs were absent in this case.

Implications:

  • Accurate diagnosis of dermatofibroma requires awareness of atypical dermoscopic findings.
  • Dermoscopy, while valuable, may not always provide a definitive diagnosis for dermatofibroma.
  • Further investigation may be needed when dermoscopic findings are unusual for suspected dermatofibroma.