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ENDOSCOPIC GASTRIC SUBMUCOSAL DISSECTION: experimental comparative protocol between standard technique and
Ernesto Quaresma Mendonça1, Lucas Snioka Zuretti1, Thiago Panzani1
1Unidade de Endoscopia Gastrointestinal, Departamento de Cirurgia, Hospital das Clínicas, Universidade de São Paulo, SP, Brasil.
Arquivos De Gastroenterologia
|July 21, 2016
Summary
The hybrid-knife technique is a viable alternative for endoscopic submucosal dissection in gastrointestinal tumor treatment. This study found no significant differences in procedure time, complications, or specimen quality compared to conventional methods.
Area of Science:
- Gastroenterology
- Surgical Endoscopy
- Oncology
Background:
- Endoscopic submucosal dissection (ESD) is a standard treatment for superficial gastrointestinal tumors.
- The efficacy and safety of pressure-jet dissection techniques within ESD remain under investigation.
Purpose of the Study:
- To compare the hybrid-knife (pressure-jet dissection) with conventional submucosal dissection techniques in a porcine model.
- To evaluate procedural time, complication rates, and specimen quality.
Main Methods:
- The study utilized a porcine model with 2 cm² antral mucosal areas marked for resection.
- The hybrid-knife was used for the experimental technique, while Flush-knife or IT-knife served as controls.
- An ERBE ICC 300 electrosurgical unit was employed for all procedures.
Main Results:
- A total of 27 interventions were performed across five animals.
- Procedural times were comparable between the hybrid-knife (9.5±3.1 min) and control knives (8.0±3.0 min), with no statistical significance (P=0.21).
- Complication rates and the quality of resected specimens were similar between the groups.
Conclusions:
- The hybrid-knife technique presents a safe and effective alternative to conventional submucosal dissection for endoscopic gastrointestinal tumor treatment.
- No significant differences were observed in procedure duration, complication incidence, or specimen quality.
