Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Spectrometry: Molecular Fragmentation Overview01:20

Mass Spectrometry: Molecular Fragmentation Overview

6.1K
The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an electron. This eventually leads to the fragmentation or breaking of some bonds in the molecule. The fragmentation occurs predominantly at specific bonds to yield relatively stable fragments.
One type of fragmentation pattern is the cleavage of a single bond in the molecular ion. The cleavage leads to a radical and a cation. The cleavage can occur at...
6.1K
Habitat Fragmentation02:31

Habitat Fragmentation

21.8K
Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
21.8K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.5K
Disassembly of Intermediate Filaments01:35

Disassembly of Intermediate Filaments

2.8K
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
2.8K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.4K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.2K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective".

Journal of medicinal chemistry·2026
Same author

A practical method for determining the rate of covalent modification of fragments and leads.

Nature communications·2025
Same author

Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity.

Molecular metabolism·2025
Same author

Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective.

Journal of medicinal chemistry·2025
Same author

Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation.

Structure (London, England : 1993)·2025
Same author

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy.

Cell reports. Medicine·2025
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

A Converging Strategy for the Generation of a Virtually Sequenced cDNA Library from Unreferenced Pacific Oysters
12:14

A Converging Strategy for the Generation of a Virtually Sequenced cDNA Library from Unreferenced Pacific Oysters

Published on: June 13, 2019

5.9K

Foreword: Pacific Fragments.

Daniel A Erlanson1

  • 1Carmot Therapeutics Inc., 409 Illinois Street, San Francisco, CA 94158, USA. derlanson@carmot.us.

Molecules (Basel, Switzerland)
|July 21, 2016
PubMed
Summary
This summary is machine-generated.

The Pacific Ocean, meaning peaceful, covers vast marine ecosystems. This research explores its diverse oceanography and biodiversity.

More Related Videos

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
07:15

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation

Published on: November 26, 2011

18.2K
Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry
09:34

Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry

Published on: September 20, 2016

11.6K

Related Experiment Videos

Last Updated: Mar 17, 2026

A Converging Strategy for the Generation of a Virtually Sequenced cDNA Library from Unreferenced Pacific Oysters
12:14

A Converging Strategy for the Generation of a Virtually Sequenced cDNA Library from Unreferenced Pacific Oysters

Published on: June 13, 2019

5.9K
Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
07:15

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation

Published on: November 26, 2011

18.2K
Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry
09:34

Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry

Published on: September 20, 2016

11.6K

Area of Science:

  • Oceanography
  • Marine Biology
  • Geology

Background:

  • The Pacific Ocean, the largest and deepest oceanic division on Earth, profoundly influences global climate and weather patterns.
  • Its geological features include the Mariana Trench and the Pacific Ring of Fire, highlighting significant tectonic activity.
  • The ocean's vastness supports a wide array of marine ecosystems, from coral reefs to deep-sea environments.

Discussion:

  • Investigating the Pacific's complex ocean currents, such as the Kuroshio and Humboldt currents, is crucial for understanding nutrient distribution and marine species migration.
  • Analyzing the impact of climate change on Pacific marine ecosystems, including coral bleaching events and changes in fish populations, is a critical area of research.
  • The study of deep-sea hydrothermal vents in the Pacific offers insights into unique chemosynthetic ecosystems and potential novel biochemical compounds.

Key Insights:

  • The Pacific Ocean plays a pivotal role in regulating global climate through its immense heat and moisture transport.
  • Biodiversity studies reveal unique species adaptations to extreme environments, such as high pressure and low temperatures in the abyssal zone.
  • Geological research underscores the dynamic nature of the Pacific basin, characterized by active volcanism and seismic activity.

Outlook:

  • Future research should focus on the long-term effects of anthropogenic stressors on Pacific marine biodiversity and ecosystem resilience.
  • Continued exploration of the Pacific's deep-sea environments may uncover new species and resources, necessitating sustainable management strategies.
  • Enhanced monitoring of oceanographic conditions will improve predictions of climate-related impacts on this vital global ocean.