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Aptasensors Based on Whispering Gallery Mode Resonators.

Gualtiero Nunzi Conti1, Simome Berneschi2, Silvia Soria3

  • 1Istituto di Fisica Applicata Nello Carrara (IFAC CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. g.nunziconti@ifac.cnr.it.

Biosensors
|July 21, 2016
PubMed
Summary

This review explores aptamer-based optical sensors using whispering gallery mode resonators (WGMRs) for medical diagnostics. Combining aptamers and WGMRs offers high sensitivity for real-time detection of diseases like cancer.

Keywords:
aptamersintegrated ringsmicrospheresoptical sensorswhispering gallery mode resonators

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Optical evanescent field sensing offers high sensitivity for biochemical detection.
  • Whispering gallery mode resonators (WGMRs) are highly sensitive optical transducers.
  • Aptamers are versatile bioreceptors with advantages over antibodies.

Purpose of the Study:

  • To review the literature on optical evanescent field sensing using aptamers in resonant cavities.
  • To highlight the potential of combining aptamer receptors with WGMR transducers for medical diagnostics.
  • To identify the current limitations and research gaps in this integrated sensing approach.

Main Methods:

  • Literature review of studies combining aptamers and WGMRs for sensing applications.
  • Analysis of the performance characteristics of WGMR-based aptasensors.
  • Discussion of the types of WGMRs and aptamer immobilization strategies employed.

Main Results:

  • The combination of aptamers and WGMRs presents a promising platform for sensitive biosensing.
  • Existing literature primarily utilizes silica microspheres and SiON ring resonators as WGMRs.
  • There is a need for more research integrating these advanced receptor and transducer technologies.

Conclusions:

  • Aptamer-functionalized WGMRs offer significant potential for real-time medical diagnostics.
  • Further research is needed to fully exploit this technology for detecting cancer, infectious diseases, and strokes.
  • This integrated approach could lead to the development of novel diagnostic devices.