Related Experiment Video
Updated: Mar 17, 2026
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
Statin-centric versus low-density lipoprotein-centric approach for atherosclerotic cardiovascular disease prevention:
Peter Yan1, Eng Kiat Kevin Tan2, Jason Chon Jun Choo3
1Peter Yan Cardiology Clinic, Gleneagles Hospital, Singapore.
Insights
Cholesterol management is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). This review addresses challenges in achieving lipid goals with statin therapy in Singaporean Asian patients and offers clinical guidance.
Area of Science:
- Cardiology
- Public Health
- Pharmacology
Background:
- Cholesterol levels are linked to atherosclerotic cardiovascular disease (ASCVD).
- Singapore faces rising ASCVD risk factors due to an aging and sedentary population.
- Current guidelines recommend statin therapy for ASCVD prevention.
Purpose of the Study:
- To review the impact of ASCVD guidelines on clinical practice in Singapore.
- To address challenges in statin therapy for Asian patients not achieving lipid goals.
- To provide principles for effective cardiovascular risk management in Singapore.
Main Methods:
- Expert consensus meeting in 2014.
- Review of current international and local ASCVD guidelines.
- Analysis of statin therapy effectiveness and lipid goal achievement in Asian populations.
Main Results:
- Asian patients may not achieve target lipid goals with current statin therapy.
- Perceived differences in statin response between Asian and Western populations.
- Need for tailored clinical practice to optimize ASCVD prevention in Singapore.
Conclusions:
- Current guidelines require adaptation for effective implementation in Singapore.
- Clinicians need principles to better manage cardiovascular risk in Asian patients.
- Addressing specific challenges in statin therapy is essential for improving ASCVD outcomes.
Abstract:
The link between cholesterol levels and atherosclerotic cardiovascular disease (ASCVD) is well-established. In Singapore, there is an increasing prevalence of risk factors for ASCVD. Like many Asian countries, Singapore's population is rapidly ageing and increasingly sedentary, which predisposes individuals to chronic health problems. Current international and local guidelines recommend statin therapy for the primary and secondary prevention of ASCVD. However, despite the effectiveness of statin therapy, some studies have highlighted that Asian patients with cardiovascular disease are not achieving target lipid goals. Furthermore, it is widely believed that the responses of Asians (both patients and physicians) to statin therapy are different from those of their Western counterparts. Experts convened in 2014 to determine the impact of current guidelines on clinical practice in Singapore. This review summarises the key findings and recommendations of these guidelines, and presents key principles to aid clinicians to manage the cardiovascular risk of their patients more effectively.
