Related Experiment Video
Updated: Mar 17, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Trichoblastoma: is a clinical or dermoscopic diagnosis possible?
G Ghigliotti1, E De Col2, A Parodi2
1I.R.C.C.S. A.O.U. San Martino-IST, Di.S.Sal, Sezione di Dermatologia, University of Genoa, Genoa, Italy. g.ghigliotti@libero.it.
Background:
Trichoblastoma is a rare benign skin tumour that must be differentiated from basal cell carcinoma for its benign course and favourable outcome.
Objectives:
To describe clinical and dermoscopic features of solitary primitive trichoblastoma and to compare them with trichoblastic basal cell carcinoma (tBCC).
Methods:
Digital dermoscopic images of 19 trichoblastoma and 19 tBCC were compared and reviewed by a dermatologist experienced in dermoscopy.
Results:
The most striking dermoscopic difference between trichoblastoma and tBCC was the presence of blue-grey globules and blue-grey ovoid nests that were found to be more frequent but not exclusive of tBCC. Arborizing vessels were found both in trichoblastoma and tBCC, with a lower frequency in the latter.
Conclusion:
Histology remains the gold standard to differentiate trichoblastoma from tBCC.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

