Related Experiment Video
Updated: Mar 17, 2026
09:10
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
7.8K
Alternative autophagy, brefeldin A and viral trafficking pathways
Charles Grose1, Daniel J Klionsky2
1a University of Iowa , Children's Hospital , Iowa City , IA , USA.
Autophagy
|July 22, 2016
Summary
This study explores how noncanonical autophagy, sensitive to brefeldin A, may intersect with viral infections. It suggests viruses utilize ER and cis-Golgi membranes for noncanonical autophagosome formation during infection.
Area of Science:
- Cellular biology
- Virology
- Molecular biology
Background:
- Autophagy research focuses on autophagosome membrane sources and noncanonical pathways.
- Understanding these pathways is crucial for cellular processes and disease.
Discussion:
- Noncanonical autophagy, brefeldin A-sensitive, may link to viral replication.
- Viruses might exploit ER and cis-Golgi membranes via noncanonical autophagy.
Key Insights:
- Convergence of autophagy research areas: membrane origin and noncanonical pathways.
- Potential mechanism for viral exploitation of host cell machinery.
Outlook:
- Further research into brefeldin A-sensitive pathways in viral infections.
- Exploring therapeutic targets at the autophagy-virus interface.
Related Concept Videos
01:36Delivery Pathways to the Lysosome
10.4K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
10.4K
01:27Autophagy
6.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
00:58Recycling Endosomes and Transcytosis
3.8K
The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
3.8K
01:38Intralumenal Vesicles and Multivesicular Bodies
5.1K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.1K
01:20Receptor-mediated Endocytosis
11.3K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
11.3K
01:38Receptor-mediated Endocytosis
113.1K
Overview
113.1K