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Updated: Mar 17, 2026
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Predictors of poor outcomes in First-Event Ischemic Stroke as assessed by Magnetic Resonance Imaging
Xiao-Yan Jia1, Ming Huang, Ya-Fen Zou
1. email@email.com.
Insights
Higher initial stroke severity and early neurologic deterioration predict poor outcomes in ischemic stroke patients. Prompt, targeted acute-stage treatment is crucial for high-risk individuals to improve prognosis.
Area of Science:
- Neurology
- Cardiovascular Research
- Public Health
Background:
- Stroke is a leading cause of death and disability globally.
- Ischemic stroke requires understanding risk factors for improved patient outcomes.
Purpose of the Study:
- To identify key predictors of poor outcomes after ischemic stroke.
- To analyze risk factors associated with adverse events and mortality.
Main Methods:
- 370 patients with first-time ischemic stroke were analyzed.
- Poor outcomes defined by Modified Rankin Scale (MRS) >3, recurrent stroke, or death.
- Stepwise logistic regression used to identify prognostic variables.
Main Results:
- 21% of patients (78/370) experienced poor outcomes.
- Higher NIHSS scores, early neurologic deterioration (END), and elevated hs-CRP levels correlated with poor outcomes.
- NIHSS and END predicted poor outcomes at 6-month follow-up.
Conclusions:
- Elevated initial NIHSS scores indicate severe deficits and increased risk.
- Early neurologic deterioration is a significant predictor of adverse outcomes.
- Focused acute-stage treatment for high-risk patients is essential.
Purpose:
Stroke is the third most common cause of mortality worldwide and is a major cause of permanent disability. The purposed of the study was to better understand the risk factors for poor outcomes following ischemic stroke requiring treatment.
Methods:
Three hundred seventy patients with first-event ischemic stroke were enrolled. Good outcomes was defined as a using the Modified Rankin Scale (MRS) score ≤3 without any cardiovascular event, while poor outcomes were any of the following end points: MRS >3 at 3 months, recurrent stroke or death. Prognostic variables for poor outcomes were analyzed based on a stepwise logistic regression model.
Results:
Seventy-eight patients had poor outcomes (21%, 78/370), assessed at a minimum of six-month follow-up. Higher mean National Institutes of Health Stroke Scale (NIHSS) scores at presentation, presence of early neurologic deterioration (END) and higher mean high-sensitivity C-reactive protein (hs-CRP) levels were associated with poor outcomes at discharge. Furthermore, both NIHSS at presentation and the presence of END were associated with poor outcomes, assessed at a minimum of six-month follow-up.
Conclusion:
A higher mean initial NIHSS score implies not only severe neurologic deficits but also an increased risk of poor outcomes. Since END following ischemic stroke is frequently associated with poor outcomes, more attention should be directed to providing adequate treatment to patients in the acute stage, especially for high risk patients.
