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APOBEC3 proteins can copackage and comutate HIV-1 genomes

Belete A Desimmie1, Ryan C Burdick1, Taisuke Izumi1

  • 1Viral Mutation Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Nucleic Acids Research
|July 22, 2016
PubMed
Summary

APOBEC3 cytidine deaminases are packaged into HIV-1 virions and can be copackaged. Copackaging of APOBEC3 proteins leads to additive or synergistic increases in G-to-A hypermutation, enhancing viral inhibition.

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