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Graves disease presenting as painful thyroiditis.

C Alves1, M S Eidson, M Zakarija

  • 1Department of Pediatrics, University of Miami School of Medicine, FL 33101.

European Journal of Pediatrics
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study presents a rare case of a 10-year-old girl with Graves disease initially presenting with a painful goiter. Despite the pain, she was successfully treated with propylthiouracil, and her symptoms resolved.

Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Thyroidology

Background:

  • Subacute thyroiditis commonly causes a painful goiter and hyperthyroidism.
  • Graves disease, an autoimmune disorder, typically presents with a non-painful thyroid gland.

Observation:

  • A 10-year-old girl presented with hyperthyroidism and a predominantly painful, tender goiter.
  • This presentation is atypical for Graves disease, which is usually painless.

Findings:

  • Graves disease was confirmed by radioactive iodine uptake scan and positive thyroid-stimulating antibody.
  • Thyrotropin-binding inhibiting IgG and anti-thyroid microsomal antibodies were also detected.
  • The patient responded well to propylthiouracil treatment, with resolution of thyroid pain.

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Implications:

  • This case highlights that Graves disease can, in rare instances, manifest with significant thyroidal pain.
  • The etiology of pain in this Graves disease case remains unclear.
  • Further research may elucidate the mechanisms behind pain in autoimmune thyroid disorders.