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The function of SH2B3 (LNK) in the kidney

Gregory Blass1, David L Mattson2, Alexander Staruschenko2

  • 1Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin gblass@mcw.edu.

American Journal of Physiology. Renal Physiology
|July 22, 2016
PubMed

Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.

Keywords:
LNKSH2B adaptor protein 3hematopoietichypertensionlymphocyte

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