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The function of SH2B3 (LNK) in the kidney
Gregory Blass1, David L Mattson2, Alexander Staruschenko2
1Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin gblass@mcw.edu.
American Journal of Physiology. Renal Physiology
|July 22, 2016
Summary
The adaptor protein SH2B3 is crucial in kidney disease progression. This review explores how SH2B3 in various kidney cells impacts renal pathologies and cytokine signaling.
Area of Science:
- Nephrology
- Immunology
- Molecular Biology
Background:
- The adaptor protein SH2B3 plays a significant role in renal disease.
- SH2B3 is predominantly expressed in hematopoietic cells and modulates cytokine signaling.
- Its presence in other kidney cell types suggests a broader function in renal health.
Purpose of the Study:
- To review the function of SH2B3-expressing cells in renal pathologies.
- To elucidate the regulatory mechanisms of SH2B3 in kidney disease.
Main Methods:
- Review of ex vivo studies identifying SH2B3 signaling targets.
- Analysis of in vivo studies examining SH2B3's role in renal disease progression.
Main Results:
- SH2B3 signaling is cell-specific and impacts cytokine regulation.
- SH2B3 influences the overall progression of renal diseases.
Conclusions:
- SH2B3 is a key regulator in kidney disease, acting through various cell types.
- Understanding SH2B3's function is vital for developing new therapeutic strategies for renal pathologies.
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