Related Experiment Video
Updated: Mar 17, 2026
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
26.7K
Preventing Diabetes: Early Versus Late Preventive Interventions.
Jaakko Tuomilehto1, Peter E H Schwarz2
1Dasman Diabetes Institute, Dasman, Kuwait Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland Center for Vascular Prevention, Danube University Krems, Krems, Austria Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia jaakko.tuomilehto@dasmaninstitute.org.
Diabetes Care
|July 22, 2016
Summary
Sustainable diabetes prevention is achievable regardless of intervention timing. Program quality and intensity should align with individual type 2 diabetes (T2D) risk, emphasizing early, varied interventions for best results.
Area of Science:
- Public Health
- Endocrinology
- Preventive Medicine
Background:
- Type 2 diabetes (T2D) prevention strategies are debated regarding optimal intervention timing.
- Early and late intervention approaches both have roles in managing diabetes risk.
- Sustainability is a key factor in the long-term success of T2D prevention programs.
Purpose of the Study:
- To evaluate the importance of sustainability in type 2 diabetes prevention programs.
- To determine the optimal timing and intensity of T2D preventive interventions.
- To compare early public health interventions with late-stage clinical interventions.
Main Methods:
- Review of arguments supporting early and late T2D prevention strategies.
- Analysis of sustainability as a critical factor in T2D prevention program effectiveness.
- Discussion of tailoring intervention quality and intensity based on T2D risk levels.
Main Results:
- Diabetes prevention is achievable through sustainable programs, irrespective of the intervention's starting point.
- Early interventions allow for a broader range of lower-intensity programs.
- Later interventions require higher intensity to manage existing pathophysiological changes and delay T2D onset.
Conclusions:
- Sustainability is paramount for effective T2D prevention, more so than the timing of intervention initiation.
- Intervention intensity and quality must be individualized according to T2D risk.
- While early interventions are preferred, late interventions can still halt dysglycemia progression and delay T2D diagnosis.
Related Concept Videos
01:30Preventive Healthcare Services
2.3K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.7K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.7K
01:22Diabetes Mellitus: Type 2 and Gestational
5.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
01:26Levels of Health Promotion and Illness Prevention
15.4K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
15.4K
01:15Diabetes: Management and Pharmacotherapy
1.3K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.3K
01:22Diabetes Mellitus: Overview and Type I Subtype
5.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.8K