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Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C
C Schächtele1, B Wagner, C Rudolph
1Gödecke Research Institute, Department of Pharmacology, Freiburg, F.R.G.
European Journal of Pharmacology
|April 12, 1989
Abstract:
Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the exception of ferdiline inhibition of the enzymes does not contribute to vascular smooth muscle relaxation.