[The immunotropic activity of GABA during cytochrome P-450 induction in the liver]

Gamma-aminobutyric acid (GABA) was shown to exert the immunodepressive effect. The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. The obtained data indicate the dependence of GABA pharmacological activity from the function of cytochrome P-450-dependent monooxygenase system of the liver.