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Updated: Mar 17, 2026

In vivo Neuronal Calcium Imaging in C. elegans

In vivo Neuronal Calcium Imaging in C. elegans

Published on: April 10, 2013

Calcium imaging with genetically encoded indicators in behaving primates.

Eyal Seidemann^1,2,3, Yuzhi Chen^1,2,3, Yoon Bai^1,2,3

¹Center for Perceptual Systems, University of Texas, Austin, United States.

|July 22, 2016

Summary

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This study introduces wide-field imaging of genetically encoded calcium indicators (GCaMP6f) in macaque V1, offering a new way to observe visual population responses. Results show these signals quantitatively relate to local neural activity, aiding brain research.

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Understanding brain function requires multi-scale neural recordings in behaving animals.
Genetically encoded calcium indicators (GECIs) offer a way to visualize neural activity.

Purpose of the Study:

To report the first results of wide-field imaging of GCaMP6f signals in the V1 of behaving macaques.
To develop computational tools for mapping wide-field signals to neural activity.

Main Methods:

Wide-field imaging of GCaMP6f signals in macaque V1.
Development of a computational model summing single-unit V1 neuron responses.
Quantitative analysis of signal tuning to stimulus properties.

Main Results:

Keywords:

behaving macaque calcium indicator neuroscience rhesus macaque widefield imaging

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Last Updated: Mar 17, 2026

In vivo Neuronal Calcium Imaging in C. elegans

In vivo Neuronal Calcium Imaging in C. elegans

Published on: April 10, 2013

Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans

Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans

Published on: February 7, 2018

Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment

Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment

Published on: February 20, 2014

Wide-field GCaMP6f imaging provides robust visual population responses at the columnar scale over large areas and long durations.
The computational model accurately predicts GCaMP signal tuning.
GCaMP signals show a linear relationship with summed local spiking activity.

Conclusions:

Wide-field GCaMP imaging is a viable technique for studying neural activity in behaving primates.
The developed computational model validates the quantitative relationship between GCaMP signals and neural population activity.
This approach advances the study of neural basis of behavior at multiple scales.