Related Experiment Video
Updated: Mar 17, 2026
05:12
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
1.7K
A developmental model for alcohol use disorders in Swedish men
K S Kendler1, H Ohlsson2, A C Edwards1
1Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Psychological Medicine
|July 23, 2016
Summary
Alcohol use disorder (AUD) is complex, influenced by genetic, psychosocial, and behavioral factors interacting over time. Externalizing behaviors were the strongest predictor in this study of Swedish men.
Area of Science:
- Psychiatry
- Genetics
- Developmental Psychology
Background:
- Alcohol use disorder (AUD) is a complex, multifactorial condition.
- Understanding the interplay of diverse risk factors across development is crucial for AUD etiology.
Purpose of the Study:
- To examine 21 risk factors for AUD across four developmental stages in a large cohort of Swedish men.
- To identify the strongest predictors and their interrelationships in the development of AUD.
Main Methods:
- Longitudinal study of 47,414 Swedish men with AUD registration data.
- Structural equation modeling was used to analyze risk factor pathways.
- Follow-up averaged 33.9 years, with AUD diagnosis at or after age 25.
Main Results:
- The final model explained 23.4% of the variance in AUD.
- Key predictors included externalizing behaviors, criminal behavior, paternal alcohol use, genetic risk, and low educational attainment.
- Familial/genetic factors (paternal alcohol use, genetic liability) and externalizing behaviors showed strong direct paths to AUD.
Conclusions:
- AUD in men is etiologically complex, driven by interacting familial-genetic, psychosocial, internalizing, and externalizing risk factors.
- These pathways are interwoven and influence each other across developmental periods.
- Externalizing behaviors represent a particularly strong pathway to AUD.
More Related Videos
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
8.7K
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
1.5K
Related Concept Videos
01:24Substance Use Disorders Affecting Sleep
521
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
521
01:17Drug Dependence
1.9K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.9K
01:28Conduct Disorder
796
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
796
01:14Psychosexual Theory of Development
3.1K
Sigmund Freud's psychosexual theory of development suggests that early childhood experiences significantly shape personality and behavior. Freud proposed that development is discontinuous, occurring in five distinct stages, each defined by a focus on different erogenous zones. He believed that failure to resolve the conflicts specific to each stage successfully could result in fixation, potentially influencing behavior as adults.
The Five Stages of Psychosexual Development
Freud's psychosexual...
The Five Stages of Psychosexual Development
Freud's psychosexual...
3.1K
02:05Self-Presentation: Self-Monitoring and Self-Handicapping
45.1K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
45.1K
01:15Drug Abuse and Addiction: Pharmacological Phenomena
1.4K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.4K