Accumbens D2: Raters of the Loss Outcome
Andrew T Marshall1, Kimberly Kirkpatrick2
1Department of Psychological Sciences, Kansas State University, 492 Bluemont Hall, 1100 Mid-Campus Drive, Manhattan, KS, 66506, USA.
Abstract:
Zalocusky et al. (Nature 531:642-646, 2016) recently showed that activity in D2R+ cells in the nucleus accumbens is associated with loss sensitivity to prior outcomes and reduced subsequent risky choice, and that optogenetic stimulation of these cells decreased risky choices in risk-prone rats. While their findings are important for understanding trait-level risk-taking, future research should aim to examine the neuronal mechanisms of a broader range of facets of gain and loss processing with respect to different potential reference points.
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