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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

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Cardiac Sarcoidosis

David H Birnie1, Pablo B Nery1, Andrew C Ha2

  • 1Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Journal of the American College of Cardiology
|July 23, 2016
PubMed

Insights

Cardiac sarcoidosis (CS) affects about 5% of sarcoidosis patients, causing heart failure, arrhythmias, and conduction issues. Silent cardiac involvement is also common, with treatment and prognosis still under investigation.

Area of Science:

  • Cardiology
  • Pulmonology
  • Immunology

Background:

  • Sarcoidosis is a multisystem inflammatory disease.
  • Cardiac sarcoidosis (CS) affects 5% of patients, manifesting as conduction abnormalities, arrhythmias, or heart failure.
  • A significant portion (20-25%) of sarcoidosis patients have asymptomatic cardiac involvement.

Purpose of the Study:

  • To summarize the key aspects of cardiac sarcoidosis diagnosis and management.
  • To highlight prognostic factors in clinically manifest CS.
  • To discuss the controversies surrounding clinically silent CS.

Main Methods:

  • Review of existing literature and guidelines on cardiac sarcoidosis.
  • Analysis of prognostic indicators in patients with manifest CS.
  • Discussion of treatment strategies including immunosuppression and device therapy.

Main Results:

  • Left ventricular dysfunction is a key predictor of prognosis in manifest CS.
  • The outcomes for patients with clinically silent CS remain debated.
  • Immunosuppression and implantable cardioverter-defibrillators are common treatment modalities for manifest CS.

Conclusions:

  • Cardiac sarcoidosis presents with diverse clinical manifestations.
  • Prognosis in manifest CS is linked to left ventricular function.
  • Further research is needed to clarify the management and outcomes of silent CS.

Keywords:
atrioventricular blockclinically manifestclinically silentheart failuresudden cardiac deathventricular arrhythmias

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