Related Experiment Video

Updated: Mar 17, 2026

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
10:24

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

12.9K

Severe gastrointestinal cytomegalovirus disease in two patients with renal vasculitis after immunosuppression

Kian-Guan Lee, Su-Hooi Teo, Cynthia Lim

    Clinical Nephrology
    |July 23, 2016
    PubMed

    Insights

    Cytomegalovirus (CMV) infection is a serious risk for patients with autoimmune kidney diseases on immunosuppressants. This review highlights severe gastrointestinal CMV disease in two renal vasculitis cases, emphasizing the need for further research.

    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Immunology

    Background:

    • Immunosuppressive therapy improves outcomes for autoimmune renal diseases but increases infectious risks.
    • Cytomegalovirus (CMV) infection is a significant cause of mortality in these patients.
    • Autoimmune renal diseases include conditions like Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).

    Observation:

    • Two cases of renal vasculitis (GPA and MPA) developed severe gastrointestinal CMV disease.
    • The patients presented with massive small bowel bleeding.
    • One patient experienced a fatal outcome due to the complications.

    Findings:

    • Severe gastrointestinal CMV disease can manifest in patients with autoimmune renal vasculitis.
    • Immunosuppression plays a critical role in the development and severity of CMV infections.
    • Massive gastrointestinal bleeding is a potential complication of severe CMV disease in this context.

    Implications:

    • Highlights the critical need for understanding the interplay between immunosuppression and CMV.
    • Suggests exploring the role of antiviral prophylaxis in high-risk patients undergoing immunosuppressive therapy.
    • Underscores the importance of vigilance for infectious complications in patients with autoimmune renal diseases.

    More Related Videos

    Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus11:18

    Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

    Published on: May 7, 2012

    13.4K
    Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice07:39

    Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice

    Published on: July 19, 2019

    11.8K

    Related Concept Videos

    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
    890
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    452
    Acute Kidney Injury III: Clinical Manifestations01:29

    Acute Kidney Injury III: Clinical Manifestations

    Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
    1.2K
    Kidney Transplant II: Surgical Procedure01:26

    Kidney Transplant II: Surgical Procedure

    Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
    705
    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    597
    Kidney Transplant I: Introduction01:28

    Kidney Transplant I: Introduction

    A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
    663