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Amoxicillin-induced aseptic meningitis: case report and review of published cases
Objective:
Amoxicillin-induced aseptic meningitis (AIAM) is an extremely rare adverse reaction with only 12 reported cases. The term aseptic meningitis refers to patients who have clinical and laboratory evidence for meningeal inflammation with negative routine bacterial cultures. Since the exact pathogenesis is still unknown and clinical signs and cerebrospinalfluid (CSF) findings vary greatly, AIAM is usually a diagnosis of exclusion.
Case Summary:
We report a clinical case of a patient referred to the clinical pharmacology outpatient clinic for consultation on suspected recurrent AIAM and a review of published cases.
Conclusions:
This report adds to the evidence-base of AIAM and emphasizes the importance of taking a thorough medication history in individuals with suspected meningitis. Considering the wide utilization of amoxicillin, it is important that healthcare providers are aware of AIAM. .
Insights
Amoxicillin-induced aseptic meningitis (AIAM) is a rare adverse reaction. Prompt recognition and a detailed medication history are crucial for diagnosing AIAM, especially given amoxicillin
Area of Science:
- Neurology
- Pharmacology
- Infectious Diseases
Background:
- Amoxicillin-induced aseptic meningitis (AIAM) is an exceptionally rare adverse drug reaction.
- Aseptic meningitis involves meningeal inflammation without bacterial infection, often a diagnosis of exclusion due to varied presentations.
- The precise pathogenesis of AIAM remains unclear, complicating diagnosis.
Observation:
- This report details a case of suspected recurrent AIAM.
- The case involved a patient referred for clinical pharmacology consultation.
- A review of previously published AIAM cases was conducted.
Findings:
- The study contributes to the limited evidence base for AIAM.
- Clinical and cerebrospinal fluid findings in AIAM can be highly variable.
- Accurate diagnosis relies on excluding other causes of meningitis.
Implications:
- Healthcare providers must maintain a high index of suspicion for AIAM.
- Thorough medication histories are essential for patients presenting with meningitis symptoms.
- Awareness of AIAM is critical due to the widespread use of amoxicillin.
