Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.

The Prostate·2007
Same author

EZH2 promotes proliferation and invasiveness of prostate cancer cells.

The Prostate·2007
Same author

Switching on the notochord.

Genes & development·1999
Same journal

Quantification of cell viability by automated analysis of live cell imaging.

Methods in cell biology·2026
Same journal

Flow cytometry evaluation of cytotoxicity exerted by effector immune cells against tumor cells.

Methods in cell biology·2026
Same journal

Time-lapse confocal laser scanning microscopy analysis of FOOD formation.

Methods in cell biology·2026
Same journal

Screening and identification of protein-protein interaction using proximity labeling.

Methods in cell biology·2026
Same journal

Quantitative high-content profiling of mitochondrial morphology with automated statistical analysis and integrated data visualization.

Methods in cell biology·2026
Same journal

Super-resolution imaging of cell death in Drosophila tissues via expansion and pan-expansion microscopy.

Methods in cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
10:06

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

23.3K

Histone modifications in zebrafish development.

V T Cunliffe1

  • 1University of Sheffield, Sheffield, United Kingdom.

Methods in Cell Biology
|July 23, 2016
PubMed
Summary
This summary is machine-generated.

Histone modifications regulate gene transcription in zebrafish development. This review details methods for analyzing these epigenetic marks and their roles in gene activation and chromatin dynamics.

Keywords:
Chromatin immunoprecipitationEpigeneticsEpigenomeHistone modificationsZebrafish

More Related Videos

Zebrafish Whole Mount High-Resolution Double Fluorescent In Situ Hybridization
12:31

Zebrafish Whole Mount High-Resolution Double Fluorescent In Situ Hybridization

Published on: March 25, 2009

24.0K
Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo
10:10

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

12.7K

Related Experiment Videos

Last Updated: Mar 17, 2026

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
10:06

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

23.3K
Zebrafish Whole Mount High-Resolution Double Fluorescent In Situ Hybridization
12:31

Zebrafish Whole Mount High-Resolution Double Fluorescent In Situ Hybridization

Published on: March 25, 2009

24.0K
Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo
10:10

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

12.7K

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Genomics

Background:

  • Reversible covalent histone modifications are crucial for spatiotemporal gene transcription during development.
  • Understanding these modifications in zebrafish offers insights into conserved developmental processes.

Purpose of the Study:

  • To review recent advances in methods for analyzing histone modification distribution and function in zebrafish chromatin.
  • To discuss the roles of dynamic histone modification patterns in zygotic gene activation and chromatin regulation.

Main Methods:

  • Chromatin immunoprecipitation (ChIP) with antibody-based detection.
  • High-throughput whole genome sequencing of chromatin immunoprecipitates.
  • Computational integration of multi-omics data (genomics, transcriptomics, methylomics).

Main Results:

  • Dynamic histone modification patterns at promoters and enhancers are key to zygotic gene activation.
  • Interplay exists between histone modification, chromatin remodeling, and DNA methylation machinery.
  • Developmentally regulated enhancers interact with modified histones.

Conclusions:

  • Advanced methods enable detailed analysis of histone modifications in zebrafish.
  • These epigenetic marks are integral to developmental gene regulation and chromatin organization.