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Related Experiment Video

Updated: Mar 17, 2026

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

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New frontiers for zebrafish management.

C Lawrence1

  • 1Boston Children's Hospital, Boston, MA, United States.

Methods in Cell Biology
|July 23, 2016
PubMed
Summary
This summary is machine-generated.

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The zebrafish (Danio rerio) model is increasingly vital across scientific fields due to its genetic similarity to mammals and advanced genome editing. Improving zebrafish husbandry is key to making research more reproducible, cost-effective, and accessible.

Area of Science:

  • * Comparative genomics and biomedical research
  • * Aquaculture and environmental toxicology

Background:

  • * Zebrafish (Danio rerio) are a prominent model organism in scientific research.
  • * Their utility is expanding beyond developmental biology into toxicology, drug discovery, and disease modeling.
  • * Genetic similarity to mammals and advancements in genome editing contribute to their growing importance.

Purpose of the Study:

  • * To highlight the expanding applications of the zebrafish model system.
  • * To emphasize the need for improved husbandry and management practices.
  • * To advocate for knowledge transfer from animal science and aquaculture.

Main Methods:

  • * Review of current zebrafish research applications.
  • * Analysis of factors driving the expanded use of zebrafish.
Keywords:
Defined environmentDiseaseHusbandryManagementNutritionZebrafish

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  • * Identification of areas for improvement in zebrafish management.

    • Main Results:

    • * Zebrafish are utilized in diverse fields including toxicology, drug discovery, transplant biology, disease modeling, and aquaculture.
    • * Genome editing technologies have accelerated their adoption.
    • * Current husbandry methods require refinement to meet the demands of expanded research.

    Conclusions:

    • * Continued growth of zebrafish research necessitates enhanced husbandry and management.
    • * Improvements will lead to more reproducible, defined, cost-effective, and accessible research.
    • * Integrating knowledge from laboratory animal science and aquaculture is crucial for progress.