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Neuroimaging in Central Nervous System Lymphoma
Seyed Ali Nabavizadeh1, Arastoo Vossough2, Mehrdad Hajmomenian2
1Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19014, USA.
Hematology/Oncology Clinics of North America
|July 23, 2016
Summary
Primary central nervous system lymphoma (PCNSL) is an aggressive brain cancer that can mimic other neurological conditions. Advanced MRI techniques help differentiate PCNSL from other disorders, aiding diagnosis and treatment.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Primary central nervous system lymphoma (PCNSL) is a rare, aggressive extranodal lymphoma.
- PCNSL presents with variable imaging features, often mimicking other brain disorders like encephalitis, demyelination, or stroke.
- The central nervous system (CNS) can also be affected by secondary involvement from systemic lymphoma.
Purpose of the Study:
- To highlight the diagnostic challenges posed by PCNSL.
- To emphasize the role of advanced MRI techniques in differentiating PCNSL.
- To inform diagnostic and therapeutic decisions for CNS lymphoma.
Main Methods:
- Review of current literature on PCNSL imaging.
- Comparison of conventional imaging (CT, conventional MRI) with advanced MRI techniques.
- Analysis of how imaging features aid in differential diagnosis.
Main Results:
- PCNSL imaging appearance can be non-specific, leading to differential diagnoses with other neurological conditions.
- Advanced MRI techniques offer improved characterization of CNS lesions compared to conventional methods.
- These advanced techniques show potential in narrowing the differential diagnosis for CNS lymphoma.
Conclusions:
- Accurate diagnosis of PCNSL is crucial due to its aggressive nature.
- Advanced MRI plays an increasingly important role in the evaluation of CNS lymphoma.
- Improved imaging can guide timely and appropriate patient management.
