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Microbial metabolism of thiopurines: A method to measure thioguanine nucleotides

Ramya Movva1, Michael Lobb2, Páraic Ó Cuív3

  • 1Immunity Infection and Inflammation Program, Mater Research Institute-University of Queensland, Brisbane, Queensland 4101, Australia; Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland 4102, Australia; School of Pharmacy, Griffith University, Queensland 4125, Australia.

Journal of Microbiological Methods
|July 23, 2016
PubMed

Keywords:
BacteriaInflammatory bowel diseaseMercaptopurineThioguanineThioguanosine

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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