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Updated: Mar 17, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

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Atypical hand, foot and mouth disease in adults associated with coxsackievirus A6: a clinico-pathologic study

Alvaro C Laga1, Suzanne M Shroba2, John Hanna3

  • 1Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. alaga@partners.org.

Journal of Cutaneous Pathology
|July 23, 2016
PubMed

Insights

Atypical hand, foot, and mouth disease (HFMD) in adults, caused by Coxsackievirus A6, presents challenging skin symptoms. Early recognition of this uncommon HFMD variant is crucial for correct diagnosis and prognosis.

Area of Science:

  • Dermatology
  • Virology
  • Infectious Diseases

Background:

  • Hand, foot, and mouth disease (HFMD) is typically a childhood illness caused by Coxsackievirus A16.
  • Adult cases are rare and can exhibit atypical, severe skin manifestations.

Observation:

  • Three adult cases of atypical HFMD were analyzed for clinical, histopathologic, and molecular features.
  • Clinical presentation mimicked erythema multiforme or herpesvirus infection.
  • Histopathology revealed intraepidermal vesiculation with neutrophil infiltrate, affecting specific skin layers.

Findings:

  • Molecular analysis identified Coxsackievirus A6 in two cases, an uncommon HFMD serotype.
  • No evidence of herpesvirus was found in any case.
  • All three patients experienced spontaneous resolution of symptoms.

Implications:

  • Atypical HFMD due to Coxsackievirus A6 is a rare but diagnostically challenging condition.
  • Accurate identification is vital to prevent unnecessary treatments and set appropriate patient expectations.
  • Understanding atypical HFMD presentations improves clinical management and diagnostic accuracy.
Abstract

Keywords:
adultcoxsackievirus A6erythema multiformehand, foot and mouth diseasehistopathology

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