Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

3.6K

Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy

Pratibha Singh1, Palaniyandi Ravanan1, Priti Talwar1

  • 1Apoptosis and Cell Survival Research Laboratory, Department of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT) University Vellore, Tamil Nadu, India.

Frontiers in Molecular Neuroscience
|July 23, 2016
PubMed

Insights

Death-Associated Protein Kinase 1 (DAPK1) is a tumor suppressor involved in apoptosis and autophagy. This review comprehensively discusses DAPK1

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Death-Associated Protein Kinase 1 (DAPK1) is a serine/threonine kinase family member.
  • DAPK1 exhibits tumor suppressive functions.
  • Dysregulation of DAPK1 is linked to cancer and neurodegenerative diseases.

Purpose of the Study:

  • To provide a comprehensive review of DAPK1.
  • To discuss the structural information of DAPK1.
  • To elucidate the cellular functions of DAPK1, including its roles in apoptosis and autophagy.

Main Methods:

  • Literature review of mechanistic studies on DAPK1.
  • Analysis of structural data related to DAPK1.
  • Synthesis of information on DAPK1's cellular functions.

Main Results:

  • DAPK1 plays a crucial role in regulating apoptosis and autophagy.
  • Structural insights into DAPK1 provide a basis for understanding its function.
  • Mechanistic studies have expanded the understanding of DAPK1's involvement in cellular processes.

Conclusions:

  • DAPK1 is a key regulator of cell death and survival pathways.
  • Understanding DAPK1's structure and function is vital for disease research.
  • Further research into DAPK1 mechanisms can inform therapeutic strategies for cancer and neurodegenerative disorders.
Keywords:
apoptosisautophagycancerdeath-associated protein kinase 1neurodegenerative disease

More Related Videos

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.6K
In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening08:16

In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening

Published on: October 6, 2022

2.0K

Related Concept Videos

Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.9K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.1K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
9.2K
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.2K
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
14.5K