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A novel method for right one-lung ventilation modeling in rabbits.

Ze-Ping Xu1, Lian-Bing Gu1, Qing-Ming Bian1

  • 1Department of Anesthesiology, Jiangsu Cancer Hospital, Jiangsu Cancer Institute, Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China.

Experimental and Therapeutic Medicine
|July 23, 2016
PubMed
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Establishing a right one-lung ventilation (OLV) model in rabbits is challenging. A novel bronchial blocker method proved effective and reliable, requiring less time and blood loss compared to other techniques.

Area of Science:

  • Anesthesiology
  • Surgical Research
  • Pulmonary Medicine

Background:

  • Standardized methods for creating right one-lung ventilation (OLV) models in rabbits are lacking.
  • OLV is crucial for thoracic surgeries but requires reliable animal models for research.

Purpose of the Study:

  • To develop and compare a novel method for establishing a right one-lung ventilation (OLV) model in rabbits.
  • To evaluate the efficacy, safety, and reliability of a self-made bronchial blocker technique against deep intubation and clamping methods.

Main Methods:

  • Forty rabbits underwent baseline two-lung ventilation (TLV) before randomization into sham (TLV) or three right-OLV groups (deep intubation, clamp, or blocker).
  • The novel blocker group involved deep intubation of a self-made bronchial blocker into the left main bronchus for 3 hours of right OLV.
Keywords:
methodsone-lung ventilationrabbits

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  • Circulatory, oxygenation, airway pressure, lung injury, time, blood loss, and success rates were assessed.

    • Main Results:

    • All OLV groups showed decreased oxygenation and increased airway pressure compared to the sham group.
    • The novel blocker method required significantly less time (6±2 min) and less blood loss (2.1±0.6 ml) compared to deep intubation and clamp methods.
    • No significant differences in lung injury scores or modeling success rates were observed between the three OLV methods.

    Conclusions:

    • Deep intubation of a self-made bronchial blocker is an easy, effective, and reliable method for establishing a right one-lung ventilation model in rabbits.
    • This novel technique offers advantages in terms of reduced procedural time and blood loss, making it suitable for research purposes.