[Methodology of chronic cardiovascular pharmacological study in the unanesthetized and unrestrained dog]

We have described and criticized the methods, techniques and materials used in our laboratory to obtain arterial and venous pressures, arterial and venous blood flows, cardiac output, internal diameter and pressure of the left ventricle, ECG and vascular diameters in unanesthetized and unrestrained dogs using both radiotelemetering systems and a direct wire connecting system.