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Wenguo Zhu¹, Niko Eckerskorn², Avinash Upadhya³

¹Laser Physics Centre, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 2601, Australia; The State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou 510275, China; Equal contribution.

Biomedical Optics Express

|July 23, 2016

Summary

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We developed an all-optical particle delivery system for X-ray Free Electron Laser (XFEL) imaging. This method uses light forces for precise, touch-free injection of biological macromolecules into the XFEL beam.

Area of Science:

Optics and Photonics
Biophysics
X-ray Science

Background:

Efficient delivery of biological macromolecules to X-ray Free Electron Laser (XFEL) beams is crucial for coherent diffraction imaging.
Existing particle injection methods face challenges in gaseous and vacuum environments.
Touch-free manipulation techniques are needed for delicate biological samples.

Purpose of the Study:

To develop an all-optical particle delivery approach for precise macromolecule injection into an XFEL beam.
To enable dynamic and stable positioning of micrometer-sized particles using light forces.
To demonstrate a method for mass measurement of single particles and potential synchronization with XFEL pulses.

Main Methods:

Utilized photophoretic and light-pressure forces (piconewton to femtonewton range) for particle manipulation.

Keywords:

(140.7010) Laser trapping (350.4855) Optical tweezers or optical manipulation

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Combined a spatial light modulator (SLM) and an electrically tunable lens (ETL) to create a variable-divergence vortex beam.

Implemented a sensorless wavefront correction approach to minimize optical aberrations.

Demonstrated optically-controlled axial motion and trapping of particles.

Main Results:

Achieved dynamic and stable positioning of levitated micrometer-sized particles under atmospheric pressure.
Demonstrated stable manipulation of optically-controlled axial motion with a 100ms response time.
Showcased modulation of trapping intensity as a method for single-particle mass measurement.
Explored phase-locking capabilities for synchronization with XFEL pulse trains.

Conclusions:

The all-optical particle delivery system offers a promising solution for touch-free injection into XFEL beams.
The developed vortex beam manipulation technique allows for precise control and stable trapping of particles.
The mass measurement capability and potential for synchronization advance particle delivery for XFEL applications.