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Hairpin extension. A general method for the improvement of sensitivity of oligonucleotide probes
1Menzies School of Health Research, Darwin, N.T., Australia.
Gene Analysis Techniques
|March 1, 1989
Abstract:
A general and sensitive detection method of target DNA is described. The system is based on an oligonucleotide probe labeled to high specific activity. This involves a novel oligonucleotide design incorporating at the 3' end a hairpin structure, allowing extension by polymerase reaction.