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Updated: Mar 17, 2026

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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
18.9K
Lyme Disease in a Young Girl
The Physician and Sportsmedicine
|July 23, 2016
Summary
Bilateral knee pain in children can be a symptom of Lyme disease, even with normal imaging. Early diagnosis and antibiotic treatment, such as tetracycline, led to a full recovery in this case.
Area of Science:
- Pediatric Orthopedics
- Infectious Diseases
- Sports Medicine
Background:
- Persistent bilateral knee pain and swelling in a pediatric patient can present diagnostic challenges.
- Standard orthopedic imaging (X-rays, bone scan) may not reveal the underlying cause of pediatric joint pain.
- Previous treatments like rest and physical therapy were ineffective, necessitating further investigation.
Purpose of the Study:
- To investigate the diagnostic utility of Lyme disease testing in pediatric patients presenting with chronic, undiagnosed knee pain.
- To highlight Lyme disease as a potential differential diagnosis in pediatric musculoskeletal complaints.
Main Methods:
- Case report of an 11 1/2-year-old female with a seven-month history of bilateral knee pain and swelling.
- Review of initial diagnostic workup including X-rays and bone scan, which were normal.
- Laboratory testing for Lyme disease was performed.
- Treatment with oral tetracycline was initiated.
Main Results:
- Laboratory studies confirmed a positive titer for Lyme disease.
- The patient experienced an uneventful recovery following antibiotic treatment.
- Resolution of knee pain and swelling was achieved.
Conclusions:
- Lyme disease should be considered in the differential diagnosis of pediatric patients with chronic knee pain and swelling, particularly when initial investigations are inconclusive.
- Prompt diagnosis and appropriate antibiotic therapy are crucial for successful management and recovery in pediatric Lyme disease presenting with joint manifestations.
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