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Updated: Mar 17, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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[Severe acne in autoinflammatory diseases].

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|July 23, 2016
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Summary
This summary is machine-generated.

Anakinra, an IL-1β inhibitor, shows promise for treating severe acne linked to autoinflammatory conditions like PASH and PAPASH syndromes, improving inflammation and healing.

Keywords:
AnakinraAutoinflammationInterleukin-1 receptor antagonistUlcer

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Area of Science:

  • Dermatology
  • Immunology
  • Rheumatology

Background:

  • Acne is increasingly recognized as a manifestation of autoinflammatory diseases, including pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) syndrome and pyogenic arthritis, PASH (PAPASH) syndrome.
  • The underlying mechanisms of these autoinflammatory conditions are not fully elucidated, but interleukin-1 beta (IL-1β) is implicated.
  • Anakinra, a recombinant human IL-1 receptor antagonist, is utilized in managing specific autoinflammatory disorders.

Observation:

  • Two cases of severe acne associated with PAPASH and PASH syndromes were treated with anakinra.
  • The patient diagnosed with PASH syndrome exhibited significant reduction in inflammation and near-complete ulcer healing.
  • The patient with PAPASH syndrome demonstrated a partial therapeutic response to anakinra treatment.

Findings:

  • Treatment with anakinra resulted in notable clinical improvement in patients with PASH and PAPASH syndromes.
  • The observed efficacy suggests a role for IL-1β in the pathogenesis of acne within these autoinflammatory disease contexts.
  • Anakinra's anti-inflammatory action appears beneficial for managing complex dermatological manifestations of autoinflammatory conditions.

Implications:

  • These findings support the investigation of IL-1β-targeted therapies for acne associated with autoinflammatory diseases.
  • Anakinra may represent a viable therapeutic option for severe, refractory cases of PASH and PAPASH syndromes.
  • Further research is warranted to explore the precise role of IL-1β in acne pathogenesis and its therapeutic targeting.