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MiRNAs-mediated cisplatin resistance in breast cancer

Xiu Chen1,2, Peng Lu3, Ying Wu4

  • 1The Fourth Clinical School of Nanjing Medical University, Baiziting42, Nanjing, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|July 23, 2016
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in cisplatin resistance in breast cancer by affecting drug response and cell survival. Understanding these miRNA mechanisms can lead to novel targeted therapies for improved breast cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cisplatin is a key chemotherapy for breast cancer.
  • Acquired or intrinsic cisplatin resistance is a major clinical challenge.
  • MicroRNAs (miRNAs) are implicated in the development of drug resistance.

Purpose of the Study:

  • To review the multifaceted roles of miRNAs in cisplatin resistance in breast cancer.
  • To elucidate how miRNAs influence key cellular processes related to drug resistance.

Main Methods:

  • Literature review of studies investigating miRNA involvement in cisplatin resistance.
  • Analysis of miRNA-mediated effects on cell survival, DNA damage, drug transport, and epigenetic modifications.

Main Results:

  • miRNAs modulate breast cancer cell survival and response to cisplatin.
  • miRNAs impact DNA damage response pathways.
  • miRNAs influence drug uptake/efflux and DNA methylation patterns.
  • Alterations in miRNA biogenesis pathways contribute to resistance.

Conclusions:

  • miRNAs are critical regulators of cisplatin resistance in breast cancer.
  • Targeting specific miRNAs offers potential therapeutic strategies.
  • Further clinical investigation is needed to translate these findings into effective treatments.
Keywords:
BreastCisplatinDrug resistancemiRNAs

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