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Four New Kaurane Diterpenoids from the Chinese Liverwort Jungermannia comata Nees
Rui-Juan Li1,2, Song Wang2,3, Gang Li2
1State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.
Abstract:
In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane-type diterpenoids, (6β)-kaur-16-ene-6,9-diol (1), (6β,12β)-kaur-16-ene-6,9,12-triol (2), (6β)-kaur-16-ene-5,6,9-triol (3), and kaur-16-ene-9,19-diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane-type diterpenoids (5 - 9) and four known trachylobane-type diterpenoids (10 - 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.
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