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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Mar 17, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Mapping and analyzing the human liver proteome: progress and potential.

Hongxiu Yu^1,2, Fang Wang¹, Ling Lin¹

¹a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.

Expert Review of Proteomics

|July 25, 2016

Summary

This summary is machine-generated.

Recent advancements in liver proteome research, including the Human Liver Proteome Project (HLPP), offer new hope for identifying biomarkers and drug targets for hepatocellular carcinoma (HCC). This progress promises improved patient outcomes.

Keywords:

Liver biomarker glycosylation liver cancer metastasis proteomics

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Area of Science:

Proteomics
Oncology
Biomedical Sciences

Background:

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide.
Understanding the liver proteome is crucial for advancing HCC research.
The Human Liver Proteome Project (HLPP) has significantly enhanced knowledge of liver biology and cancer.

Purpose of the Study:

To summarize recent progress in liver proteome research, focusing on modification profiles and proteomic studies in HCC.
To highlight the search for novel biomarkers and drug targets for liver cancer.
To report on the advancements of the Chromosome Centric Human Proteome Project (CHPP) at Fudan University's Institutes of Biomedical Sciences (IBS).

Main Methods:

Review of recent proteomic studies and findings related to liver cancer.
Analysis of progress within the Human Liver Proteome Project (HLPP) and Chromosome Centric Human Proteome Project (CHPP).
Synthesis of data on liver proteome modification profiles.

Main Results:

Significant progress has been made in understanding liver proteome modification profiles.
Proteomic studies have identified potential novel biomarkers and drug targets for HCC.
The CHPP initiative has contributed valuable data to liver cancer research.

Conclusions:

Recent findings offer substantial promise for improving the clinical outcomes of HCC patients.
Continued proteomic research is vital for developing more effective HCC diagnostics and therapeutics.
Collaborative efforts like HLPP and CHPP are accelerating discoveries in liver cancer research.