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Updated: Mar 17, 2026

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Published on: October 27, 2014
WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?
Victoria Sherwood1, Irene M Leigh1
1Division of Cancer Research, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Abstract:
The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cutaneous squamous cell carcinoma. WNT pathways are aberrantly regulated in multiple tumor types (albeit in a context-dependent manner), and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cutaneous squamous cell carcinoma and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
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