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Related Experiment Video

Updated: Mar 17, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Trabecular meshwork stiffness in glaucoma.

Ke Wang¹, A Thomas Read¹, Todd Sulchek²

¹Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.

Experimental Eye Research

|July 25, 2016

Summary

This summary is machine-generated.

Trabecular meshwork (TM) stiffness alterations are linked to primary open-angle glaucoma (POAG). This study introduces a new method for measuring TM stiffness in mice, aiding research into glaucoma

Keywords:

Biomechanics Glaucoma Outflow facility Stiffness Trabecular meshwork

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Published on: May 3, 2016

Area of Science:

Ocular biomechanics
Glaucoma research
Trabecular meshwork (TM) physiology

Background:

Alterations in TM stiffness are implicated in primary open-angle glaucoma (POAG), a leading cause of blindness.
Existing data suggest a correlation between elevated intraocular pressure (IOP) and increased TM stiffness, but the causal link is not fully understood.
Understanding TM biomechanical properties is crucial for elucidating POAG pathogenesis.

Purpose of the Study:

To review current literature on TM stiffness measurement techniques and factors influencing TM stiffness.
To introduce a novel cryosection/atomic force microscopy (AFM)-based method for measuring TM stiffness in mice.
To investigate the relationship between TM stiffness and outflow facility in different mouse strains.

Main Methods:

Comprehensive literature review of TM stiffness measurement techniques (e.g., AFM, uniaxial tension, beam deflection).
Development and application of a cryosection/AFM approach for direct TM stiffness quantification in mouse models.
Comparative analysis of TM stiffness and outflow facility between C57BL/6J and CBA/J mouse strains.

Main Results:

Preliminary data demonstrate the feasibility of the cryosection/AFM method for mouse TM stiffness assessment.
Identified differences in TM stiffness between C57BL/6J and CBA/J mouse strains.
Explored correlations between TM stiffness and outflow facility in the studied mouse strains.

Conclusions:

The developed cryosection/AFM method offers a promising tool for direct TM stiffness measurements in mice.
Further research using this method can enhance understanding of the mechanistic links between TM biomechanical properties and ocular outflow.
This work contributes to the ongoing effort to unravel the role of TM biomechanics in POAG pathogenesis.